Editorial: Inflammation, Tumor Necrosis Factor, and Toxicology
نویسندگان
چکیده
منابع مشابه
Inflammation, tumor necrosis factor, and toxicology.
At the recent Society of Toxicology annual meeting in March, Debra Laskin of Rutgers University presented the Burroughs Wellcome Toxicology Scholars Award Lecture titled "Mechanisms of Chemical Toxicity: The Dark Side of the Immune System," which described the role of inflammatory processes in exacerbating hepatotoxicity after use of the common pain reliever acetaminophen. The role of inflammat...
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The tumor necrosis factor superfamily (TNFSF) and its corresponding receptor superfamily (TNFRSF) form communication pathways required for developmental, homeostatic, and stimulus-responsive processes in vivo. Although this receptor-ligand system operates between many different cell types and organ systems, many of these proteins play specific roles in immune system function. The TNFSF and TNFR...
متن کاملCachectin/tumor necrosis factor induces cachexia, anemia, and inflammation
Cachexia is a potentially lethal syndrome of unknown etiology characterized by anorexia, weight loss, and protein wasting that frequently complicates the treatment of chronic inflammation and cancer. Cachectin/TNF was isolated during the search for a humoral mediator of cachexia and found to stimulate the breakdown of energy stores from adipocytes and myocytes in vitro, but the chronic effects ...
متن کاملTumor necrosis factor and anti-tumor necrosis factor therapies.
Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states. This section discusses TNF, its receptors, and its role in immunoregulation and inflammation, as well as the currently available anti-TNF-...
متن کاملEvaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1998
ISSN: 0091-6765
DOI: 10.2307/3434211